Tumorigenicity was unsuccessfully tested in various mouse systems and finally established in a zebra fish model. Mutation analysis by next-generation sequencing, copy number profiling, and cytogenetics demonstrated the different genetic profile of MUG-Mel1 and clones. We succeeded to establish a brain melanoma metastasis cell line, namely MUG-Mel1 and two resulting clones D5 and C8 by morphological variety, differences in lipidome, growth behavior, surface, and stem cell markers. ![]() Our focus was to reveal the potential heterogeneity of melanoma brain metastasis. ![]() Treatment opportunities have been restricted until now and new therapy options are urgently required. Melanoma is a leading cause of high mortality that frequently spreads to the brain and is associated with deterioration in quality and quantity of life.
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